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Ion-conducting pathways of C1C2 (left), GtACR1 (middle) and iC++ (right). Black meshes represent the extracellular and intracellular vestibules. Red dashed circles represent ECSs. Note that EV1 and EV2 of iC++ are structurally more similar to the extracellular vestibules of GtACR1 than those of C1C2.
