An official website of the United States government
Here's how you know
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Figure 1: Schematic of nutlin-based PROTAC and its component ligands.
(A) structure of the BRD4/BET inhibitor, JQ1; (B) structure of idasanutlin (RG7388), an MDM2 antagonist; (C) structure of A1874, an MDM2-recruiting, BRD4-degrading PROTAC.