Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Cancer Res. 2018 Nov 1;79(1):251–262. doi: 10.1158/0008-5472.CAN-18-2918

Figure 3: Cell viability assay of cell lines treated with A1874 compared to its component ligands.

Figure 3:

(A) HCT116 colorectal cancer cells; (B) A375 melanoma cells; (C) NCI-H2030 lung cancer cells; (D) HT29 colorectal cancer cells; (E) p53−/− HCT116 colorectal cancer cells (isogenic with panel (A)). A1874 data points that are asterisked exhibit synergistic activity compared to the sum of the component warhead activities at the same concentration according to Bliss Independence model (32).