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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Structure. 2018 Nov 8;27(1):66–77.e5. doi: 10.1016/j.str.2018.10.002

Figure 2. Solvent accessibility of Nurr1 LBD probed by HDX-MS.

Figure 2.

Deuterium uptake curves show that peptides within the putative LBP have high solvent exchange (blue) relative to the low-to-moderate exchange observed for peptides within the core of the Nurr1 LBD (green) and other solvent exposed peptides on the surface of the Nurr1 LBD (red). Data represent the mean and s.d. of three experimental replicates. Analyzed peptide fragments are colored according to structural location and displayed on the Nurr1 LBD (PDB 1OVL; chain B).