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PP2A activation combined with mTOR inhibition as a therapeutic strategy to reduce PDA survival. A. Oncogenic KRAS drives the activation of both the MYC and PI3K/AKT/mTOR pathways. Upon mTOR inhibition, PDA cells capitalize on low PP2A levels, signaling through MYC for survival, creating a MYCHigh/mTORLow cell state. B. Activation of PP2A combined with mTOR inhibition results in low MYC and mTOR signaling in a MYCLow/mTORLow cell state, decreasing PDA cell survival.
