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. Author manuscript; available in PMC: 2019 Jan 3.
Published in final edited form as: Curr Pharm Des. 2018;24(28):3376–3383. doi: 10.2174/1381612824666180924102530

Figure 5. Flavonoids in cardioprotection from IR injury.

Figure 5.

Mice underwent 60 min of ischemia and 120 min of reperfusion. Infarct sizes were measured by double staining with Evan’s blue and triphenyl-tetrazolium chloride. Infarct sizes are expressed as the percent of the area at risk (AAR) that underwent infarction. C57BL/6 wildtype mice received vehicle (solutol in 0.9% NaCl [ratio 1:100]) or nobiletin (1mg/kg) equimolar doses of flavone (0.55 mg/kg), tangeritin (0.93 mg/kg), sinensetin (0.93 mg/kg), 5,6,7-trimethoxyflavone (0.78 mg/kg), or 3’,4’,7,8-tetramethoxyflavone (0.85 mg/kg) in solutol:0.9%NaCl (ratio 1:100) 2 hours prior to myocardial ischemia via intraperitoneal injection. (A) Infarct sizes as the percent of AAR; (B) flavone; (C) nobiletin; (C) tangeritin; (E) sinensetin; (F) 3’,4’,7,8-tetramethoxyflavone; (G) 5,6,7-trimethoxyflavone; (n=5–8; mean±SD; p<0.05).