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Minimum tumor radius achieved during treatment as a function of drug strength dependent on (A) size of tumor tissue viable (proliferating and hypoxic) fraction and (B) intratumoral vascular fraction (vascular surface area divided by tumor area), both calculated at the start of the treatment. The tumor vasculature-induced tissue heterogeneity increases from VERY LOW (leftmost point) to HIGH (rightmost point), while the drug strength increases with shorter IC50 times.
