Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Cancer Res. 2018 Nov 6;79(1):61–71. doi: 10.1158/0008-5472.CAN-18-1087

Figure 1. Krt6a-positive cells in K6a-tva/MMTV-Wnt1 mammary glands are enriched for precancerous stem cells.

Figure 1.

(A) Experimental design of limiting dilution transplantation (LDT). (B) Representative whole mount image of the outgrowth of Lin-TVA+ cells in the #4 cleared fat pad of a recipient mouse. The inset shows the endogenous #2 gland of the same recipient mouse. Scale bar = 1mm. (C) Lin-TVA+ cells give rise to multiple cell lineages. IHC images show the expression of different cell type markers in the outgrowth of Lin-TVA+ cells. Scale bar = 20μm. Lin: non-epithelial cell lineage markers.