Flow diagram of participants included in the current analysis. 1 Identified as of Puerto Rican descent. 2 Met the exclusion criteria (eg, serious illness, moved from the study area, homeless, or hostile). 3 Reasons for declining participation (eg, not interested, too busy, did not want blood drawn, length of study, or doctor/spouse advised against participation). 4 Low Mini-Mental State Examination Score (MMSE<10). 5 Participants with valid depressive symptomatology and plasma PLP data. 6 Baseline participants with 2y follow-up data. 7 Baseline participants with 5y follow-up data.