Table 4.

Longitudinal Associations between Depressive symptomatology (CES-D) and time-varying suboptimal PLP status in the Puerto Rican Health study participants

	Model 1 a			Model 2 b			Model 3 c			Model 4 d			Model 5 e
	β	(SE)	p-value	β	(SE)	p-value	β	(SE)	p-value	β	(SE)	p-value	β	(SE)	p-value
Suboptimal Vitamin B-6 (plasma PLP<30 nmol/L)
No -ref					-			-			-			-
Yes	0.72	0.54	0.18	0.70	0.54	0.20	1.30	0.50	0.01	1.29	0.56	0.02	1.14	0.55	0.04
Time	−0.68	0.07	<0.0001	−0.67	0.07	<0.0001	−0.66	0.08	<0.0001	−0.79	0.10	<0.0001	−0.81	0.10	<0.0001
Suboptimal Vitamin B-6 * Time
No -ref		-			-			-			-
Yes	0.08	0.16	0.61	0.03	0.16	0.83	−0.12	0.16	0.48	0.07	0.22	0.73	0.11	0.22	0.63
Goodness of fit
Df	12			14			17			21			22
N (CES-D score: Level-1 data)	3427			3393			3099			2407			2399
N (participants: Level-2 data)	1446			1435			1304			1169			1169
Log Likelihood (LL)	−13036			−12896			−11381			−8821			−8766
Akaike Information Criterion (AIC)	26097			25819			22796			17677			17575
Bayesian Information Criterion (BIC)	26170			25905			22899			17775			17703

^aModel 1: adjusted for age + sex + education + BMI

^bModel 2: Model 1 + smoking, and alcohol use

^cModel 3: Model 2 + stressful life events, perceived stress, and allostatic load

^dModel 4: Model 3 + time-varying plasma vitamins B-12, Folate, baseline plasma vitamin D + baseline energy adjusted magnesium diet intake

^eModel 5: Model 4 + time-varying antidepressant drug use