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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Nutr Neurosci. 2018 Jan 16;22(9):625–636. doi: 10.1080/1028415X.2017.1422904

Table 4.

Longitudinal Associations between Depressive symptomatology (CES-D) and time-varying suboptimal PLP status in the Puerto Rican Health study participants

Model 1 a Model 2 b Model 3 c Model 4 d Model 5 e
β (SE) p-value β (SE) p-value β (SE) p-value β (SE) p-value β (SE) p-value
Suboptimal Vitamin B-6 (plasma PLP<30 nmol/L)
No -ref - - - -
Yes 0.72 0.54 0.18 0.70 0.54 0.20 1.30 0.50 0.01 1.29 0.56 0.02 1.14 0.55 0.04
Time −0.68 0.07 <0.0001 −0.67 0.07 <0.0001 −0.66 0.08 <0.0001 −0.79 0.10 <0.0001 −0.81 0.10 <0.0001
Suboptimal Vitamin B-6 * Time
No -ref - - - -
Yes 0.08 0.16 0.61 0.03 0.16 0.83 −0.12 0.16 0.48 0.07 0.22 0.73 0.11 0.22 0.63
Goodness of fit
Df 12 14 17 21 22
N (CES-D score: Level-1 data) 3427 3393 3099 2407 2399
N (participants: Level-2 data) 1446 1435 1304 1169 1169
Log Likelihood (LL) −13036 −12896 −11381 −8821 −8766
Akaike Information Criterion (AIC) 26097 25819 22796 17677 17575
Bayesian Information Criterion (BIC) 26170 25905 22899 17775 17703
a

Model 1: adjusted for age + sex + education + BMI

b

Model 2: Model 1 + smoking, and alcohol use

c

Model 3: Model 2 + stressful life events, perceived stress, and allostatic load

d

Model 4: Model 3 + time-varying plasma vitamins B-12, Folate, baseline plasma vitamin D + baseline energy adjusted magnesium diet intake

e

Model 5: Model 4 + time-varying antidepressant drug use