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Comparison of EwS and BRCA-mutant cancers
| Phenotype | BRCA1/2 mutant cancers | Ewing sarcoma |
|---|---|---|
| Sensitivity to DNA damaging agents | ✔ | ✔ |
| Sensitivity to PARP1 inhibitors | ✔ | ✔ |
| Hyperactivation of PARP1 | ✔ | ✔ |
| Impaired homologous recombination | ✔ | ✔ |
| Accumumation of R-loops | ✔ | ✔ |
| High expression of EZH2 | ✔ | ✔ |
