Biochemical assay of renal function and histological morphology data in different groups of mice. (a) Urinary albumin excretions, (b) creatinine clearance rate, (c) plasma creatinine levels, (d) plasma fasting glucose levels, (e) mesangial matrix fractions, (f) interstitial fibrosis area ratios, (g) glomerular basement membranes thickness, (h) foot process width, (i) glomerular tuft area. The data are expressed as the mean ± SD. *P < 0.05, ***P < 0.001 vs. WT group; #P < 0.05 vs. db/db group