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. 2018 Dec 4;29(1):23–41. doi: 10.1038/s41422-018-0113-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Prrc2a deficiency reduces oligodendroglia proliferation. a Volcano plot of RNA-seq data shows Prrc2a-regulated genes from brain tissue samples of 4-week-old Prrc2a^f/f; Nestin^Cre+/- vs. control mice. b Representative Gene Ontology (GO) terms of the biological process categories enriched in transcripts with upregulated (left) or downregulated (right) expressions from Prrc2a^f/f; Nestin^Cre+/- vs. control samples. c GSEA plots evaluating the changes in oligodendroglial lineage-specific genes, the neuronal genes and astrocytic genes in Prrc2a^f/f; Nestin^Cre+/- vs. control brain tissue samples. Note that FDR < 0.25 is statistically significant for GSEA analysis: www.broadinstitute.org/gsea/doc/GSEAUserGuideFrame.html. (see also Supplementary information, Table S4-6). d Schematic cartoon of oligodendroglia developmental stages: OPC, premyelinating, and ultimately myelinating oligodendroglia. The below table shows the down-regulated DEGs that control oligodendroglia-specific stage development. e Relative gene expression in hippocampus tissue from 4-week-old mice with indicated genotypes (one-way ANOVA followed Tukey test, *P < 0.05, **P < 0.01, ***P < 0.001, f/f, n = 6; f/ + ; Nes, n = 4; f/f; Nes, n = 6). f Immunostainings of Pdgfrα (P7), CC1/Olig2, or Sox10 (P28) in corpus callosum from mice with indicated genotypes. The quantification of Pdgfrα⁺, CC1⁺ Olig2⁺, or Sox10⁺ cells was shown in (g) (one-way ANOVA followed Tukey test, *P < 0.05, **P < 0.01, ***P < 0.001, Pdgfrα⁺ cells, n = 8 each group, CC1⁺ Olig2⁺ cells, f/f, n = 5, f/ + ; Nes n = 4, f/f; Nes n = 5, Sox10⁺ cells, n = 4 each group)