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Schematic overview of interactions between NETosis, platelets, and coagulation. a The interaction between activated platelets and neutrophils. b Platelet-derived HMGB1 can induce NETosis. c Platelets can interact with C3b and histones on NETs, which stimulate the excretion of polyP. d Multiple factors can cause thrombin cleavage on NETs. e NE is able to generate thrombin-derived immune modulatory peptides. f Fibrin fibers strengthened by NETs are less prone to degradation by plasmin
