Fig. 7.

Proposed model. We propose here a model in which centrioles sense acto-myosin force organization and respond via regulating centriole separation. Moreover, the degree of acto-myosin organization modulates PLK4 recruitment at the centrosome to ultimately control centriole duplication. In the proposed scenario, the PLK4 recruitment at the centrosome is inversely proportional to the degree of force organization: an excessive recruitment of PLK4 due to disorganization of acto-myosion forces triggers aberrant centriole duplication. On the contrary, well-aligned acto-myosin forces ensures the right amount of PLK4 at the centrosome and the correct centriole duplication