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Concentration–time curve of DEX in the kidney (a) and kidney cortex (b) after the intravenous injection of 90 nm A-DEX NPs or A-DEX solution in rats. The AUC (0→t) (μg/L*h) of 90 nm A-DEX NPs or A-DEX solution in the kidney was 1441.15 ± 65.41 or 1134.94 ± 56, respectively. The AUC (0→t) (μg/L*h) of 90-nm A-DEX NPs or A-DEX solution in the kidney cortex was 1567.40 ± 32.57 or 1140.99 ± 36.26, respectively. Data for each time point are expressed as the mean ± SD (n = 5). #P < 0.05
