Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 25;29(1):8–22. doi: 10.1038/s41422-018-0103-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Characterization of HepLPCs. a Principal component analysis of PHCs (freshly isolated), hepatic hepatoma cell lines (HepG2), hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), fetal hepatocytes (Fetal.Hep) and HepLPCs at day 4, day 10, passage 5 and passage 10 in TEM from two donors based on global gene expression profile. b K-mean analysis of hepatic function related genes (top) and cell cycle related genes (bottom) in PHCs and cells at day 4, day 10, passage 5 and passage 10 in TEM. c Correlation scatter plot show the changes of liver progenitor related genes by KEGG enriched analysis. Passage 5 or passage 10 versus PHCs (P0). d QPCR analyses for the expression of liver progenitor related genes, PHCs were freshly isolated (one-way ANOVA with Dunnett correction for multiple comparisons, n = 4 donors, n.s., non-significant, *P < 0.05, **P < 0.01, ***P < 0.001). e t-SNE projection of all 7459 individual HepLPCs based on K-means clustering, different colors represent different subgroups. f Heatmap of liver progenitor- and hepatic lineage-related genes in different subgroups