Fig. 1.

Regulation of memory strength by METTL3. Left panel: METTL3-mediated m⁶A modification might influence translation efficacy, mRNA transport and local translation of IEGs by m⁶A readers and writers to modulate learning-induced plasticity in neurons. Right panel: Lack of m⁶A modification in METTL3-deficient animals prevents additional mRNA processing and leads to decreased levels of IEGs, and decreased memory performance. The decrease in IEG translation might be overcome by m⁶A modification-independent mechanisms induced through increased learning