Table 1.

The permeability characteristics of BBR and the five other PAs across the Caco-2 monolayer model in vitro (n = 3, three parallel wells)

	Papp (AP-BL) (×10−6 cm/s)	Papp (BL-AP) (×10−6 cm/s)	Net effluxa (×10−6 cm/s)	ERb
BER (10 μM)	3.64 ± 0.84	70.60 ± 9.70	66.69 ± 9.35	19.92
BBR (10 μM)	0.08 ± 0.04	2.63 ± 0.70	2.55 ± 0.67	33.54
COL (10 μM)	0.34 ± 0.02	1.94 ± 0.09	1.6 ± 0.07	5.68
JAT (10 μM)	0.50 ± 0.15	2.23 ± 0.28	1.73 ± 0.42	4.84
THA (10 μM)	0.89 ± 0.20	1.22 ± 0.07	0.35 ± 0.02	1.51
DEM (10 μM)	0.09 ± 0.04	0.31 ± 0.01	0.22 ± 0.05	3.71

^aNet efflux = P_{app (BL-AP)} − P_{app (AP-BL)}

^bER = P_{app (BL-AP)}/P_{app (AP-BL)}