Table 3.
Association between MSH2 MSI, MSH6 MSI and MSH2 MSI- MSH6 MSI with Clinicopathological Features of CRC
| Clinicopath-ological Features | CI 95% | CI 95% | CI 95% | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSH2 MSI | OR | Lower | Upper | P value | MSH6 MSI | OR | Lower | Upper | P Value | MSH2- MSH6 MSI | OR | Lower | Upper | P Value | |
| Age | 0.41 | 0.04 | 4.10 | 0.444 | 0.88 | 0.25 | 3.08 | 0.844 | 0.59 | 0.05 | 7.01 | 0.676 | |||
| <50 y.o | 1 (1.4%) | 6 (8.3%) | 1 (1.4%) | ||||||||||||
| ≥50 y.o * | 5 (6.9%) | 20 (27.8%) | 4 (5.6%) | ||||||||||||
| Sex | 1.98 | 0.31 | 12.63 | 0.471 | 1.40 | 0.46 | 4.31 | 0.553 | 4.93 | 0.45 | 53.80 | 0.190 | |||
| Male* | 4 (5.6%) | 17 (23.6%) | 4 (5.6%) | ||||||||||||
| Female | 2 (2.8%) | 9 (12.5%) | 1 (1.4%) | ||||||||||||
| Tumor Size | - | - | - | - | - | - | - | - | - | - | - | - | |||
| T1-T2 | 0 (0%) | 0 (0%) | 0 (0.0%) | ||||||||||||
| T3-T4* | 6 (9.8%) | 22 (36.1%) | 5 (8.2%) | ||||||||||||
| Tumor Location | 1.47 | 0.10 | 20.99 | 0.776 | 2.53 | 0.51 | 12.58 | 0.256 | - | - | - | - | |||
| Colon* | 5 (6.9%) | 18 (25.0%) | 5 (6.9%) | ||||||||||||
| Rectum | 1 (1.4%) | 8 (11.1%) | 0 (0.0%) | ||||||||||||
| Tumor Stage | 1.48 | 0.16 | 13.75 | 0.732 | 0.49 | 0.11 | 2.10 | 0.336 | 1.69 | 0.14 | 20.49 | 0.681 | |||
| Early | 3 (4.2%) | 9 (12.7%) | 3 (4.2%) | ||||||||||||
| Late* | 3 (4.2%) | 17 (23.9%) | 2 (2.8%) | ||||||||||||
| Tumor Differenti-ation | 0.52 | 0.03 | 8.05 | 0.639 | 3.02 | 0.44 | 20.66 | 0.260 | 0.29 | 0.01 | 7.33 | 0.449 | |||
| Non-Poor | 5 (6.9%) | 23 (31.9%) | 4 (5.6%) | ||||||||||||
| Poor* | 1 (1.4%) | 1 (1.4%) | |||||||||||||
*
references