Fig. 1. Histopathological examination of the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE) with or without Ishige okamurae treatment. There was no infiltration of inflammatory cells in the spinal cord of normal control rats (A, D). The spinal cords of vehicle-treated EAE rats contained many inflammatory cells (arrowheads) (B, E) in the parenchyma, whereas the number of inflammatory cells (arrowheads) (C, F) in the spinal cords of I. okamurae-treated rats (10 mg/kg body weight) was reduced. Hematoxylin and eosin staining. Arrowheads indicate inflammatory cells. Scale bars=200 µm (A–C) and 50 µm (D–F).