Table 1. Effect of Ishige okamurae ethanolic extract on the clinical symptoms of EAE in rats.

	Incidence of EAE (paralyzed/total animals)	First onset of paralysis	Average maximum clinical score	Duration of paralysis (day)
Treatment from day –1 to +14 PI		10.1
Vehicle control	8/8	10.1±1.4	2.4±0.8	6.4±0.8
I. okamurae 1 mg/kg	5/5	9.4±0.5	2.6±0.5	6.4±0.5
I. okamurae 10 mg/kg	5/5	13.8±2.7**	1.4±0.5	4.4±0.9***
I. okamurae 50 mg/kg	4/4	16.3±0.7***	2.3±0.9	3.8±1.5***

Values are presented as mean±standard errors. EAE, experimental autoimmune encephalomyelitis; PI, post-immunization. ^**P<0.01, ^***P<0.001 vs. vehicle-treated control (Student's unpaired two-tailed t-test).