Table 1.

mACE2-rAAV2/8 therapy increased hepatic ACE2 expression, resulting in a marked reduction in biliary fibrosis in a long-term model of chronic biliary fibrosis (Mdr2-KO mice)

Stage of the disease	Hepatic ACE2 expression, fold	Liver fibrosis reduction, %
Early: 3-6 mo	60	50%
Advanced: 7-9 mo	160	80%