Fig. 11. Di-(2-ethylhexyl) phthalate (DEHP) induce apoptosis of cerebellar granule cells (CGCs). The apoptosis induced by DEHP is associated with inhibition of the PI3K/AKT signaling pathway. Insulin-like growth factor (IGF) 1 may partially protect CGCs from apoptosis and LY294002 aggravated the apoptosis induced by DEHP.