Figure 6.

Top: Reaction scheme of the formation of CMC hybrid hydrogels. The reaction involves the formation of an amide bond between the carboxylic groups of CMC and the amine groups of the amino-functionalized metal oxide nanoparticles (cross-linkers) in the presence of EDC and NHS; Bottom: Ball-and-stick molecular model of DOX (doxorubicin) and comparison of its release from Fe₃O₄-CMC hydrogel composite in NaCl 0.15 M in the absence of magnetic field (circles), in the presence of an AMF (squares) and with SMF (triangles). Adapted with permission from reference [52] and reference [54]. Copyrights ^© 2011 Royal Society of Chemistry and ^© 2015 MDPI, respectively.