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Graft copolymerization of NIPAAm and CNC via free radical polymerization employing ammonium persulfate (APS) as initiator and 1,2-di-(dimethylamino)ethane (TEMED) as accelerator (up) and schematic representation of metronidazole drug loading and release upon the action of the volume phase transition temperature (VPTT) at 37 °C (down). Adapted with permission from reference [52]. Copyright © 2017 Polymers MDPI.
