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. 2017 Jul 13;3(3):28. doi: 10.3390/gels3030028

Figure 3.

Figure 3

Focal adhesion kinase (FAK) expression increases with elastic modulus. (A) Immunofluorescent staining for phosphorylated FAK in U373 cells, A172 cells and U87EGFRvIII cells at S1, S2, and S3. Scale bars—100 μm; (B) Increased resolution imaging of FAK expression at S3. Scale bars—50 μm. (C–F) Proliferation of glioblastoma (GBM) cell types on varying elastic moduli under inhibition of FAK phosphorylation with defactinib: U373 cells (C), A172 cells (D), U87 (E) and U87 EGFRvIII cells (F). * denotes p-value was less than 0.05 when S1 and S3 values were compared, & denotes p-value was less than 0.05 when values of S2 and S3 were compared, and # denotes when the p-value was less than 0.05 when S1 and S2 values were compared.