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Gene-Modified Human CD34+-Derived Cells Traffic to Tissues
Anti-GFP IHC staining of the GFP+ gene-modified cells in the spleen (A), small intestine (B), mesenteric lymph nodes (LN) (C), and GALT (D) from mock, GFP-only, or PGT128-GFP mice. Red dotted lines, GALT. Right, 20× magnification from the indicated region of the left (10× magnification). Tissues were collected at necropsy, 34 weeks post-infusion.
