Table 2.
Defining clusters of VFs within bacterial species
| Escherichia coli | Klebsiella pneumoniae | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VFs | Total (n=148) | Cluster grouping | VF | Total (n=82) | Cluster grouping | ||||||
| No VF (n=19) | Siderophore exclusive (n=62) | Siderophore exclusive with iroN (n=29) | Adhesin sfa/papGIII-rich (n=14) | Adhesin papC/papGII-rich (n=24) | KP common VF (n=40) | KP common VF with ybtS (n=27) | KP common VF with kfu (n=15) | ||||
| fyuA | 106 (72) | 0 (0) | 50 (80) | 24 (83) | 10 (71) | 22 (92) | ybtS | 36 (44) | 0 (0) | 27 (100) | 9 (60) |
| hly | 22 (15) | 0 (0) | 0 (0) | 0 (0) | 11 (79) | 11 (46) | mrkD | 81 (99) | 39 (98) | 27 (100) | 15 (100) |
| sfa/foc | 11 (7) | 0 (0) | 0 (0) | 1 (3) | 10 (71) | 0 (0) | entB | 82 (100) | 40 (100) | 27 (100) | 15 (100) |
| papC | 37 (25) | 0 (0) | 0 (0) | 2 (7) | 11 (79) | 24 (100) | rmpA | 1 (1) | 0 (0) | 1 (4) | 0 (0) |
| iucC | 102 (69) | 0 (0) | 54 (87) | 23 (79) | 5 (36) | 20 (83) | kfu | 15 (18) | 0 (0) | 0 (0) | 15 (100) |
| papGIII | 11 (7) | 0 (0) | 1 (2) | 0 (0) | 9 (64) | 1 (4) | allS | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| papGII | 20 (14) | 0 (0) | 0 (0) | 1 (3) | 1 (7) | 18 (75) | iutA | 2 (2) | 0 (0) | 2 (7) | 0 (0) |
| cnf1 | 22 (15) | 0 (0) | 1 (2) | 2 (7) | 11 (79) | 8 (33) | magA | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ibeA | 15 (10) | 0 (0) | 1 (2) | 7 (24) | 3 (21) | 4 (17) | |||||
| iroN | 42 (28) | 0 (0) | 0 (0) | 29 (100) | 11 (79) | 2 (8) | |||||
Note: Clusters of VFs were determined among bacterial species, E. coli and K. pneumoniae, using k-medians clustering with the Jaccard similarity measure.
Abbreviation: VFs, virulence factors.