Figure 1.

(A) A section of the H&E-stained biopsy containing normal tissue and tumor is shown with a superimposed and magnified image highlighting the tumor from which laser-capture microdissection (LCM) was performed. Diagnosis revealed the single focal grade 1 endometrioid endometrial adenocarcinoma, stage IA, without evidence of myometrial invasion. (B) An overview of the mutational profile of the six patients, including the index case, possessing PTEN 130 mutations. The sum of all mutations—driver, potential driver, and unknown significance—is shown for each patient.