Figure 5.

ELISA-Based Quantification of PMOs in Serum and Muscle

(A) Plots show the concentrations of each PMO in the cocktail found in weekly serum samples from treated CXMD_J dogs. Different colors indicate individual dogs. Black arrows in the topmost plot represent times of injection; numbers beside the arrows indicate how many days post-injection sample collection was done. (B) The concentrations of each of the four PMOs in various muscles are shown. Muscles were collected 2–3 weeks after the final injection. Different colors indicate individual dogs. For 10504MA, data for the left ventricle (LV) is not available, while for 9202MA, data for the biceps brachii (BIC), diaphragm (DIA), and LV are not available. For both (A) and (B), n = 4–6 (PMO-treated). Abbreviations: TA, tibialis anterior; GAS, gastrocnemius; IC, intercostal muscles; DIA, diaphragm; SC, sternocleidomastoid.