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. 2019 Jan;44(1):21–32. doi: 10.1016/j.tibs.2018.10.010

Table 2.

Summary of Annotation Databases and Postanalysis Tools Helpful in Making Sense of Results in Computational Analytics

Annotation database/Tool name Description Link
UniProt Comprehensive proteomics knowledge base (functions, pathways, sequences, modifications, literature references, ID conversion). https://www.uniprot.org
BioMart Gene-centric database with ID conversion, genomic features (such as exons, introns, untranslated regions), sequences, positions of genes in the genome. https://www.ensembl.org/biomart/martview/
NCBI Genome Data Viewer A Web tool for exploration and analysis of eukaryotic genome assemblies. https://www.ncbi.nlm.nih.gov/genome/gdv/
UCSC Genome Browser A collection of tools for analysis of genomes with a plethora of available data ‘tracks’ such as epigenetic signals and genomic features. https://genome.ucsc.edu/
StringDB A database of known and predicted protein–protein interactions. Integrates functional relationship data from various sources. https://www.string-db.org/
BioGRID Curated database of physical and genetic interactions based on various experimental sources. https://thebiogrid.org/
DAVID Gene Ontology and pathway analysis Web tool for calculation of functional enrichments in lists of genes or proteins. https://david.ncifcrf.gov/
Enrichr Web tool for calculating various functional enrichments in lists of genes or proteins. https://amp.pharm.mssm.edu/Enrichr/
g:Profiler Web tools for functional profiling of groups of genes or proteins. Contains useful ID conversion and orthology mapping tools. https://biit.cs.ut.ee/gprofiler/