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. 2019 Jan 3;20:2. doi: 10.1186/s12931-018-0963-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Treatment with a novel RXR partial agonist prevents CSE-induced emphysematous changes. a Experimental protocol. b (a) Lm values, (b) DI values. c Representative photographs of H&E-stained lung tissue (magnification: X200) (a) PBS/vehicle, (b) CSE/vehicle, (c) CSE/NEt-4IB 0.015%. (D) Cst values. The results for each group are expressed as the means ± SEM. This experiment was started with 7 mice in PBS/vehicle, and 11 mice in CSE/vehicle, PPE/NEt-4IB 0.015%. No mice were died during the experimental period. * Significant differences (P < 0.05) between PBS/vehicle and CSE/vehicle. # Significant differences (P < 0.05) between CSE/vehicle and CSE/NEt-4IB 0.005%. CSE, cigarette smoke extract