Table 1.
Characteristics of included stuides
| RCT, year, dose, duration | Treatment (numbers) | Outcomes | Adverse events | IELT (SD) | PE definition |
|---|---|---|---|---|---|
| Gammel et al. [20] 2013 20 mg 4 weeks Sunay et al. [21] 2011 20 mg 4 weeks Safarinejad et al. [22] 2006 20 mg 12 weeks | on-demand tramadol 50 mg/d (29), sildenafil 50 mg/d (30), paroxetine 20 mg/d (28), local lidocaine gel (30), placebo (27) daily paroxetine 20 mg/d (30), acupuncture (30), placebo (30), daily dapoxetine 60 mg/d (104), paroxetine 20 mg/d (105), placebo (100), daily dapoxetine 60 mg/d (104), paroxetine 20 mg/d (105), placebo (100) | IELT, sexual satisfaction scores IELT, PEDT IELT, IIEF, weekly intercourse episodes IELT, IIEF, weekly intercourse episodes | all adverse events were tolerable no side effects were observed well tolerated | 5.85 (1.98), 3.8 (1.15), 3.1 (1.08), 2.97 (1.85), 1.35 (0.54) 1.17, 1.17, 0.42 2.98, 6.17, 0.92 | IELT < 2 min in > 70% of sexual intercourse episodes IELTs of < 2 min in > 70% of coital attempts IELT < 2 min that occurred in > 90% of episodes of sexual inter course |
| Gong et al. [18] 2011 20 mg 4 weeks Ozcan et al. [33] 2015 20 mg 1 month | daily paroxetine 20 mg/d (40), placebo (40) daily duloxetine 40 mg/d(40), daily paroxetine 20 mg/d (40) | IELT, sexual satisfaction scores IELT, IIEF, PEP | well tolerated well tolerated | 5.75 (1.24), 1.06 (0.28) 2.09 (0.12), 2.14 (0.15) | DSM-IV-TR lifelong PE |
| Abdel-Hamid et al. [24] 2001 20 mg 4 weeks | on-demand clomipramine 25 mg, on-demand sertraline 50 mg, on-demand paroxetine 20 mg, on-demand sildenafil 50 mg and the pause-squeeze technique | IELT, sexual satisfaction scores | mild to moderate | 4, 3, 4, 15, 3 | IELT ≤2 min |
| Abu et al. [23] 2018 30 mg 6 weeks | on-demand sildenafil 50 mg/d combined with dapoxetine 50 mg/d (30), sildenafil 50 mg/d (30), paroxetine 30 mg/d (30), dapoxetine 30 mg/d (30), placebo (30) | IELT, PEDT, sexual satisfaction | well tolerated | 4.43, 2.93, 2.90, 2.86, 0.69 | IELT ≤1 min |
| Otunctemur et al. [27] 2014 20 mg 4 weeks | daily fluoxetine 20 mg/d (20), sertraline 50 mg/d (20), paroxetine 20 mg/d (20), healthy control (40) | IELT | not mentioned | 2.5 (0.69), 3.09 (1.15), 3.70 (0.86) | IELT < 1 min |
| KIrecci et al. [29] 2014 20 mg 4 weeks a | daily sertraline 50 mg/d (8), paroxetine 20 mg/d (8), healthy control (11) | IELT, IIEF | not mentioned | 1.89 (0.51), 1.92 (0.49) | IELT < 1 min, primary PE |
| Kirecci et al. [28] 2014 20 mg 4 weeks b | daily sertraline 50 mg/d (20), paroxetine 20 mg/d (20), fluoxetine 20 mg/d (20) | IELT, IIEF | tolerated | 1.71 (0.98), 1.78 (0.62), 1.55 (0.64) | lifelong PE (IELT of < 1 min) |
| Wang et al. [15] 2007 20 mg 6 months | on-demand sildenafil 50 mg/d (59), paroxetine 20 mg/d (649), squeeze technique (38) | IELT, PE grade, intercourse satisfaction score, frequency of intercourse | well tolerated | 6.21 (1.86), 4.93 (1.36), 2.62 (0.69) | IELT < 2 min, primary PE |
| Alghobary et al. [25] 2010 20 mg 6 weeks | on-demand tramadol 50 mg/d (17), daily paroxetine 20 mg/d (18) | IELT, AIPE, libido, erection | well tolerated | 3.00,3.84 | DSM-IV-TR, lifelong PE |
| Polat et al. [26] 2015 20 mg 1 month | daily paroxetine 20 mg/d (50), on-demand tadalafil 20 mg (50), on-demand paroxetine 20 mg combined tadalafil 20 mg (50) | IELT, IIEF | well tolerated | 1.96 (1.12), 1.84 (0.62), 2.92 (1.00) | lifelong PE |
| Waldinger et al. [19] 1998 20 mg 6 weeks | placebo (9), fluvoxamine 100 mg/d (10), fluoxetine 20 mg/d (10), paroxetine 20 mg/d (11), sertraline 50 mg/d (11), | IELT | well tolerated | 0.48 (0.41), 55 (70), 3.5 (4.18), 7.9 (19.1), 1.95 (1.45) | lifelong PE (IELT of < 1 min) |
| Shao et al. [32] 2008 20 mg 8 weeks | paroxetine 20 mg/d (40), behaviour therapy (40), paroxetine 10 mg/d combined behaviour therapy (40) | IELT, CIPE-5 | well tolerated | 4.4 (0.5), 4.2 (0.4), 4.8 (0.5) | not mentioned |
| Moudi et al. [16] 2016 10 mg 6 months Zhang et al. [30] 2012 20 mg 12 weeks Hamidi-Madani et al. [17] 2018 20 mg 12 weeks Arafa et al. [31] 2007 20 mg 4 weeks | paroxetine 10 mg/d (50), paroxetine 10 mg/d combined tadalafil 10 mg/d (50) behaviour therapy (22), paroxetine 20 mg/d (32), paroxetine 30 mg/d (32), daily sertraline 50 mg/d (28), daily sertraline 100 mg/d (30) on-demand tramadol 50 mg/d (48), paroxetine 20 mg/d (46), placebo (32) daily fluoxetine 20 mg/d (33), escitalopram 10 mg/d (37), paroxetine 20 mg/d (30) | IELT, IIEF IELT, sexual satisfaction IELT, PEP AIPE, IELT | well tolerated well tolerated well tolerated, well tolerated, | 4.8 (1), 5.3 (2)—— 2.29 (1.29), 1.52 (1.23), 1.30 (0.92) 2.4 (0.4), 2.5 (0.3), 2.7 (0.2) | lifelong PE (IELT of < 1.5 min) not mentioned lifelong PE (IELT of < 1 min) IELT ≤2 min |
RCT randomized, controlled trial, IELT intravaginal ejaculatory latency time, PEP premature ejaculation profile, IIEF international index of erectile function, AIPE Arabic index of premature ejaculation, CIPE-5 Chinese index of premature ejaculation, PEDT premature ejaculation diagnostic tool, PE premature ejaculation, SD standard deviation, DSM-IV Diagnostic and Statistical Manual of Mental Disorders, fourth edition