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. 2018 Dec 28;24(48):5491–5504. doi: 10.3748/wjg.v24.i48.5491

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Serial near-infrared fluorescence imaging of a representative mouse bearing xenografted tumor. A: Imaging was performed pre- and post- injection of indocyanine green (ICG)-labeled anti-tissue factor antibody 1849 (1849-ICG) at indicated time points (24, 48, 72, and 144 h). The upper panel shows the overlaid image of the ICG spectrum image (middle panel) and the white light image (lower panel). Fluorescent signal intensity of BxPC-3 tumors is higher than that of the whole body. Adjoining bar graph shows the ICG specific signal intensity of the tumors over time with the peak intensity at 24 h after the injection. Data are presented as mean ± SD (n = 14); B: Images of tumor bearing mice before photoimmunotherapy (PIT) (left); 2 h (center) and 24 h (right) after PIT. ICG signal intensity in the tumor decreased initially after PIT and was restored in 24 h suggesting re-accumulation of 1849-ICG due to circulating 1849-ICG. Bar graph shows the ICG signal intensity of tumor before and after near-infrared-PIT. Data are presented as mean ± SD (n = 16). 1849-ICG: Indocyanine green-labeled anti-tissue factor antibody 1849; NIR: Near-infrared; PIT: Photoimmunotherapy.