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. 2018 Dec 28;24(48):5477–5490. doi: 10.3748/wjg.v24.i48.5477

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of RIP3 on inflammatory markers. A and B: TNF-α/LPS + zVAD induced increase in TNF-α expression was exacerbated with GSK'843 treatment. TNF-α/LPS + zVAD induced increased expression of CXCL1 and CXCL2 was decreased with GSK'843 treatment. ^aP < 0.05 by ANOVA, Duncan post hoc analysis, compared to control; ^bP < 0.05 by ANOVA, Duncan post hoc analysis. TNF-α: Tumor necrosis factor alpha; LPS: Lipopolysaccharide; zVAD: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone; CXCL1: Chemokine (C-X-C motif) ligand-1; CXCL2: Chemokine (C-X-C motif) ligand-2; ANOVA, Analysis of variance.