Table 2.

Amount of radiographic change at 7 years overall, for those free of radiographic osteoarthritis (OA) at baseline, and also separately for baseline hand OA subsets, stratified by gender in the imputed data (n = 706).

	Females			Males
	n	Adjusted mean*	(95% CI)	n	Adjusted mean*	(95% CI)
Outcome = KL summed score (0–80) †
Total	438	17.0	(15.8, 18.2)	268	12.5	(11.2, 13.8)
No baseline hand OA	123	9.0	(7.1, 10.9)	98	6.8	(4.7, 8.8)
Thumb base OA	199	21.0	(19.6, 22.5)	104	16.1	(14.0, 18.1)
Nodal IPJ OA	115	26.6	(23.6, 29.5)	37	21.5	(17.7, 25.4)
Generalized hand OA	61	31.6	(28.0, 35.2)	22	27.6	(21.5, 33.7)
Erosive OA	19	40.1	(34.9, 45.3)	3	–	–
Outcome = Number of hand joints with KL grade ≥ 2 (0–20) †
Total	437	6.7	(6.2, 7.2)	268	5.3	(4.7, 5.8)
No baseline hand OA	123	3.6	(2.9, 4.4)	98	2.8	(2.0, 3.7)
Thumb base OA	198	8.2	(7.7, 8.8)	104	6.6	(5.8, 7.4)
Nodal IPJ OA	114	10.5	(9.3, 11.7)	37	9.4	(7.9, 11.0)
Generalized hand OA	60	12.1	(10.7, 13.4)	22	10.8	(8.9, 12.8)
Erosive OA	18	13.5	(11.6, 15.4)	3	–	–

*Adjusted for baseline value of outcome measure, cohort, age, and time to follow-up; †one individual was excluded owing to maximum number of joints affected at baseline (n = 20); – unable to calculate owing to small numbers.

CI, confidence interval; KL, Kellgren–Lawrence; IPJ, interphalangeal joint; No hand OA = KL < 2 in all hand joints; Nodal IPJ OA = KL ≥ 2 in ≥ 2 IPJs (rays 2–5) and ≥ 2 nodes (rays 2–3) across either hand; Thumb base OA = KL ≥ 2 in the first carpometacarpal (1CMCJ) in either hand; Generalized hand OA = KL ≥ 2 in ≥ 1 distal IPJ and ≥ 1 proximal IPJ and ≥ 1 1CMCJ across either hand; Erosive OA = ≥ 2 IPJs (rays 2–5) across either hand.