Table 4.
Association between baseline metabolic factors and incident hand osteoarthritis (OA) at 7 years in those free of radiographic hand OA at baseline.
| Analysis based on multiply imputed data | |
|---|---|
| Participants free of hand OA at baseline (n = 221) | |
| Outcome = KL summed score (0–80) | |
| |
Adjusted mean difference* (95% CI) |
| BMI (kg/m2) † | 0.05 (−0.18, 0.28) |
| Hypertension | −0.26 (−2.70, 2.18) |
| Diabetes type 2/IFG | 0.66 (−3.25, 4.57) |
| Dyslipidaemia |
−0.22 (−2.83, 2.40) |
| No. of metabolic factors (0–4) † |
−0.36 (−1.40, 0.68) |
| Metabolic syndrome ‡ |
−0.15 (−3.53, 3.22) |
| Outcome = Number of hand joints with KL grade ≥ 2 (0–20) § | |
| |
Adjusted mean difference* (95% CI) |
| BMI (kg/m2) † | 0.02 (−0.08, 0.12) |
| Hypertension | −0.20 (−1.19, 0.79) |
| Diabetes type 2/IFG | 0.04 (−1.48, 1.55) |
| Dyslipidaemia |
0.16 (−0.92, 1.23) |
| No. of metabolic factors (0–4) † |
−0.15 (−0.59, 0.28) |
| Metabolic syndrome ‡ |
−0.07 (−1.52, 1.39) |
| |
Complete case analysis |
| Participants free of hand OA at baseline (n = 126) | |
| Outcome = KL summed score (0–80) | |
| |
Adjusted mean difference* (95% CI) |
| BMI (kg/m2) † | 0.10 (−0.12, 0.33) |
| Hypertension | −0.34 (−2.45, 1.78) |
| Diabetes type 2/IFG | −0.25 (−3.78, 3.29) |
| Dyslipidaemia |
0.04 (−2.35, 2.43) |
| No. of metabolic factors (0–4) † |
−0.16 (−1.13, 0.81) |
| Metabolic syndrome ‡ |
−0.15 (−3.26, 2.96) |
| Outcome = Number of hand joints with KL grade ≥ 2 (0–20) § | |
| |
Adjusted mean difference* (95% CI) |
| BMI (kg/m2) † | 0.02 (−0.08, 0.11) |
| Hypertension | −0.19 (−1.12, 0.74) |
| Diabetes type 2/IFG | −0.42 (−1.98, 1.13) |
| Dyslipidaemia |
0.08 (−0.98, 1.13) |
| No. of metabolic factors (0–4) † |
−0.16 (−0.59, 0.27) |
| Metabolic syndrome ‡ | −0.11 (−1.47, 1.26) |
*Estimated from analysis of covariance adjusted for baseline value of outcome measure, cohort, time to follow-up, gender, age, Index of Multiple Deprivation, and smoking status; †per unit increase (all other factors are classed as present/absent); ‡any three of body mass index (BMI) ≥ 30 kg/m2, diabetes type 2/impaired fasting glucose (IFG), hypertension, and dyslipidaemia; §one individual was excluded owing to maximum number of joints affected at baseline.
KL, Kellgren–Lawrence; CI, confidence interval.