Fig. 3.

Seed detection and testing related to overall accuracy in the pantomime task. The three seeds found in correlations between overall accuracy and whole-brain connectedness are shown to the left. For each seed, two rows of corresponding seed-to-whole-brain results are shown to the right. The top row for each seed shows permutation-corrected results (cluster size) of seed-to-voxel functional connectivity that is positively correlated with overall accuracy at differing levels of significance (levels of P < .05 down to P < .001). The colors indicate the lowest p-value in this range that was found to be significant (from green, P < .05, ranging down to red, P < .001). The second row for each seed shows permutation-corrected group comparisons of patients versus controls (P < .05, 2-tailed) for seed-to-voxel functional connectivity. In all cases, these group comparisons followed the pattern of patients < controls (weaker functional connectivity in patients), with voxelwise significance level shown using color (p-values ranging from green, P < .05, down to red, P < .1.0 × 10⁻⁰⁷). As the group comparisons were also false-discovery rate (FDR) corrected at a voxelwise threshold of P < .05 (q <.05), the significance level for these plots is shown on a continuous scale rather than at discrete intervals. For inclusion in later analyses, all behavioral correlations had to survive at least a P < .005 threshold in both runs and additionally show a significant difference between patients and controls (P < .05).