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. 2018 Nov 13;27(1):17–28. doi: 10.1016/j.ymthe.2018.11.004

Figure 1.

Figure 1

miR-212/132 Inhibits Doxorubicin-Induced Apoptosis and Atrophy in Cardiomyocytes

(A) Caspase 3/7 activity in primary neonatal rat cardiomyocytes after pre-miR-Neg, pre-miR-132, and pre-miR-212 transfection followed by 0.1 μM doxorubicin treatment for 48 hr. Percentage of TUNEL-positive cardiomyocytes (B and C) and cardiomyocyte cell size (D and E) in pre-miR-Neg-, pre-miR-132-, and pre-miR-212-transfected primary neonatal rat cardiomyocytes, with or without doxorubicin, are indicated. (F and G) Cell size measurements of human iPSC-derived cardiomyocytes transfected with pre-miR-Neg, pre-miR-132, and pre-miR-212, in the presence or absence of doxorubicin, are indicated. *p < 0.05; **p < 0.01; ***p < 0.001. RLU, relative luminescence unit; iPSC-CM, iPSC-derived cardiomyocyte.