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. 2018 Nov 13;27(1):17–28. doi: 10.1016/j.ymthe.2018.11.004

Figure 4.

Figure 4

AAV9-miR-212/132 Prevents Doxorubicin-Induced Cardiac Apoptosis and Atrophy

(A) Representative transmission electron microscope images of AAV9-control hearts, AAV9-control hearts with doxorubicin, and AAV9-miR-212/132 hearts with doxorubicin showing myofibril structures. (B and C) Heart sections showing TUNEL-positive nuclei in AAV9-control healthy hearts (n = 7), AAV9-control hearts with doxorubicin (n = 10), and AAV9-miR-212/132 hearts exposed to doxorubicin (n = 8). (D and E) Wheat germ agglutinin staining showing cardiomyocyte cell size in AAV9-control healthy hearts (n = 11), AAV9-control hearts with doxorubicin (n = 11), and AAV9-miR-212/132 hearts exposed to doxorubicin (n = 8). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.