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. 2018 Nov 15;27(1):188–199. doi: 10.1016/j.ymthe.2018.10.016

Figure 3.

Figure 3

In Vivo Expression and Kinetics of MdaPCSK9

(A) Quantitative ELISA analysis for MdaPCSK9 following a single intramuscular injection of DMAb plasmids in B6.Cg-foxn1nu/J nude mice. (B) Quantitative ELISA analysis for MdaPCSK9 following a single intramuscular injection of DMAb plasmids in C57BL/6J wild-type mice. (C) Sequential administrations of MdaPCSK9 by intramuscular injection in C57BL/6J wild-type mice at days 0, 21, and 42. Quantitative ELISA analysis was performed for MdaPCSK9 at the indicated time points. Plates were coated with recombinant mouse PCSK9 protein, followed by incubation with anti-mouse IgG-HRP for the detection of MdaPCSK9. Values represent mean expression in each group (n = 5) ± SEM.