Table 2. Pharmacokinetic parameters from six dogs treated with a single EC0531 dose of 0.28 mg/kg given intravenously.
| Dog # | t1/2 (min) | Tmax (min) | Cmax (ng/mL) | C0 (ng/mL) | AUClast (hr*ng/mL) | AUCinf (hr*ng/mL) | Vz (L/kg) | Cl (L/hr/kg) | Tmax (min)^ | Cmax (ng/mL)^ |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 22.0 | 2.0 | 4400 | 4971 | 2299 | 2305 | 0.0643 | 0.121 | 10.0 | 2.0 |
| 2 | 19.9 | 2.0 | 5270 | 6187 | 2801 | 2806 | 0.0477 | 0.100 | 10.0 | 4.0 |
| 3 | 26.3 | 2.0 | 2630 | 2840 | 1552 | 1563 | 0.1134 | 0.179 | 10.0 | 3.2 |
| 4 | 26.5 | 2.0 | 2920 | 3335 | 1679 | 1681 | 0.1062 | 0.167 | 10.0 | 2.2 |
| 5 | 26.4 | 2.0 | 3300 | 3641 | 2082 | 2084 | 0.0853 | 0.134 | 2.0 | 1.8 |
| 6 | 27.3 | 2.0 | 2410 | 2976 | 939 | 941 | 0.1956 | 0.298 | 30.0 | 0.7 |
| Avg | 24.7 | 2.0 | 3488 | 3992 | 1892 | 1896 | 0.102 | 0.167 | 12.0 | 2.3 |
| SD | 3.03 | 0 | 1119 | 1319 | 647 | 648 | 0.052 | 0.071 | 9.4 | 1.1 |
The dogs included (in order in the table): a 15 year old, 23 kg, neutered male Norwegian Elkhound; a 9 year old, 27 kg, spayed female mixed breed dog; a 13 year old, 7 kg, spayed female Tibetan Terrier; a 14 year old, 13 kg, neutered male Fox Terrier; an 11 year old, 17 kg, spayed female Border Collie; and a 9 year old, 11 kg, spayed female Scottish Terrier.
^EC0347 (free drug) data.