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. Author manuscript; available in PMC: 2020 Jan 4.
Published in final edited form as: Circ Res. 2019 Jan 4;124(1):32–37. doi: 10.1161/CIRCRESAHA.118.314191

Table 4.

Side-Effects Reported at Least Once During PCSK9 Inhibitor
Treatment(N=271)
Musculoskeletal symptoms 22 (8.1%)
Injection site reactions 16 (5.9%)
Problems with Injection Technique 15 (5.6%)
Flu-like Symptoms 15 (5.5%)
Fatigue 9 (3.3%)
Nasopharyngitis 8 (3.0%)
GI Symptoms 5 (1.8%)
Headache 5 (1.8%)
Cognitive Issues 4 (1.5%)
Dizziness 3 (1.1%)
Erectile dysfunction 2 (0.7%)
Depression 2 (0.7%)
Hot Flashes 1 (0.4%)
Discontinuation rates due to side effects 13 (5%)
*

Of the 13 patients who discontinued therapy due to side effects, the reasons cited were: myalgias (4); flu-like symptoms (3); cognitive issues (2); depression (1); fatigue (1); diarrhea (1); dermatologic (1)