Table 3.

Serum concentration of cholesterol, HDL, LDL, triglycerides, uric acid, as well as aspartate and alanine aminotransferase during the study.

	Before statin	After statin	Δ after–before statin 95% CI	p Value	Before placebo	After placebo	Δ after–before placebo 95% CI	p Value	Δ Statin/placebo 95% CI	Statin/placebo therapy p value
Total cholesterol (mg/dl)	225.5 [50]	195 [41]	–34.0 ± 32.8 (95% CI –45 to –23)	<.001	218 [55]	212 [49]	–5.3 ± 24.1 (95% CI –13.4 to 2.8)	.9	–28.6 ± 37.8 (95% CI –41.3 to –15.9)	<.001
HDL-cholesterol (mg/dl)	56.9 ± 16.7	63.7 ± 17.9	6.7 ± 12.5 (95% CI 2.5–10.9)	.003	56 [27]	56 [31.3]	0.6 ± 10.8 (95% CI –3.0 to 4.2	.8	6.1 ± 13.3 (95% CI 1.7–10.5)	.04
LDL-cholesterol (mg/dl)	146 ± 28	107 ± 26	–38.4 ± 29.1 (95% CI –48.2 to –28.6)	<.001	146 [24]	144 [40]	–5.2 ± 20.2 (95% CI –11.9 to 1.5)	.9	–32.3 ± 31.0 (95% CI –42.7 to –21.9)	<.001
Triglyceride (mg/dl)	165 [36]	145 [43]	–23.8 ± 36.9 (95% CI 36.2 to –11.4)	.02	154 [25]	149 [31]	–5.3 ± 17.8 (95% CI –11.2 to 0.6)	.03	–18.5 ± 36.9 (95% CI –30.8 to –6.1)	.01
Uric acid (mg/dl)	7.5 ± 1.3	7.1 ± 1.2	–0.4 ± 0.9 (95% CI –0.7 to 0.1)	.01	7.2 ± 1.4	7.1 ± 1.2	–0.2 ± 0.8 (95% CI –0.4 to 0)	.1	–0.2 ± 1.2 (95% CI –0.6 to 1.0)	.3
AspAT (U/L)	24.5 [10.7]	28 [11.7]	4.5 ± 11.8 (95% CI 2.1–6.9)	.003	21 [6.7]	21 [9]	1.1 ± 5.1 (95% CI –0.6 to 2.8)	.1	3.4 ± 13.5 (95% CI –1.1 to 7.9)	.3
AlAT (U/L)	29.4 ± 12.5	32.3 ± 12.5	2.1 ± 7.8 (95% CI –0.5 to 4.7)	.04	26.1 ± 8.9	27.1 ± 9.4	0,8 ± 2.7 (95% CI –0.1 to 1.7)	.09	–2.9 ± 9.2 (95% CI –5.9 to 0.1)	.2

Results are expressed as mean ± SD in the case of non-normally distributed variables or [median (IQR)] in the case of non-normally distributed variables.

AspAT: aspartate aminotransferase; AlAT: alanine aminotransferase.