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Structure of proline‐modified short hairpin ribonucleic acid (PshRNA). Structure of canonical double‐strand small interfering RNA (siRNA) and novel single‐strand RNA interference (PshRNA) agents. Blue circles indicate the sense strand of a target gene, red circles are the antisense strand and yellow circles are the linker region. P indicates a proline derivative. RNAi, ribonucleic acid interference.
