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. 2018 Aug 22;27(1):107–116. doi: 10.4062/biomolther.2018.090

Fig. 2.

Fig. 2.

Chronic treatment of sulfuretin prevents obesity in HFD-fed obese mice. (A) Sulfuretin treatment decreased body weight gain in HFD-fed mice. Eight-week-old male C57BL/6J mice were fed a normal diet (ND, 20% fat) or a high fat diet (HFD, 60% fat) and treated with a vehicle or sulfuretin (5 mg/kg or 10 mg/kg) for 8 weeks. Mice were weighed every four days (n=8 per group). (B) Significant differences in the area under the curve (AUC) of body weight changes. (C) Sulfuretin treatment did not affect food intake. Data indicate means ± SD (n=8 per group). (D) Organ weights of mice fed with high-fat diets and treated with a vehicle control or sulfuretin. Sulfuretin treatment decreased epididymal fat (eWAT) and liver weight gains but not kidney or spleen weights in the HFD-fed mice. Data represent means ± SEM (n=8 per group). Statistical significance was determined relative to a control by a Student’s t-test (**p<0.005, ***p<0.001, n.s., not significant).