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. 2018 Jan 12;11(1):e001856. doi: 10.1161/CIRCGEN.117.001856

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© 2018 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure. — Odds ratio (OR) for coronary heart disease according to tertiles of polygenic risk score (PRS) and smoking status. Individuals who are in the lowest tertile of PRS and are never smokers were considered as a reference group. Smoking was associated with higher risk for coronary heart disease among individuals within each tertile of PRS. The magnitude of relative risk increase by smoking was higher among individuals with low PRS (OR, 1.42; 95% confidence interval [CI], 1.29–1.56) compared with individuals with high PRS (OR, 1.20; 195% CI,.11–1.30). Never smokers in the highest tertile of PRS had a similar risk (OR, 1.97; 95% CI, 1.64–2.37) to current smokers (OR, 1.99; 95% CI, 1.68–2.37) in the lowest tertile of PRS compared with the reference group.