Figure 2.

Collagen antibody–induced arthritis (CAIA) does not alter the expression levels of CGRP, SP or galanin in the spinal dorsal horn. Relative expression based on assessment of fluorescence intensity of (A) CGRP, (B) SP, and (C) galanin, as well as (D) representative images of immunoreactivity in the lumbar spinal cord of male and female mice 15 and 54 days after CAIA induction. Data are presented as mean ± SEM, n = 8 mice per group, male vs female CAIA mice on day 54, ^##P > 0.01. CGRP, calcitonin gene–related peptide; SP, substance P.