Figure 2.

The value of plasma xanthine oxidase (XO) activity did not show apparent diurnal variation and was not altered by meals or aerobic mild exercise in lean patients without diabetes. (a) In lean patients without diabetes, plasma XO activity was measured at the point of 08.00, 15.00 and 23.00 hours, and 08.00 hours in the next day (n = 5). (b) In patients now being treated with insulin or oral drugs for hyperuricemia, plasma XO activities were measured before/after breakfast and before/after lunch (large graph, n = 5), as well as before/after ~1 h of mild aerobic exercise in another group (small graph, n = 5). Data are expressed as mean ± standard error of the mean, and were analyzed by Wilcoxon signed‐rank tests. BB, before breakfast; AB, after breakfast; BL, before lunch; AL, after lunch; BE, before exercise; AE, after exercise; IXP, isoxanthopterin.